Neonatal Citrulline Supplementation and Later Exposure to a High Fructose Diet in Rats Born with a Low Birth Weight: A Preliminary Report
نویسندگان
چکیده
A low birth weight (LBW) leads to a higher risk of metabolic syndrome in adulthood. Literature suggests that citrulline supplementation in adulthood prevents the effect of a high fructose diet on energy metabolism. Whether neonatal citrulline supplementation would alter early growth or energy metabolism in the long-term in rats with LBW is unknown. LBW pups born from dams fed a low (4%) protein diet, were nursed by normally-fed dams and received isonitrogenous supplements of either l-citrulline or l-alanine by gavage from the sixth day of life until weaning, and were subsequently exposed to 10%-fructose in drinking water from weaning to 90 days of age. The oral glucose tolerance was tested (OGTT) at 70 days of age, and rats were sacrificed at 90 days of age. Pre-weaning citrulline supplementation failed to alter the growth trajectory, OGTT, plasma triglycerides, or fat mass accretion in adulthood; yet, it was associated with increased liver triglycerides, decreased liver total cholesterol, and a distinct liver lipidomic profile that may result in a predisposition to liver disease. We conclude that pre-weaning supplementation with citrulline does not impact early growth, but might impact liver fat metabolism in adulthood upon exposure to a high fructose diet.
منابع مشابه
Effect of Cinnamon and Turmeric Aqueous Extracts on Serum Interleukin-17F Level of High Fructose-Fed Rats
Background: Studies have indicated that extraweight and obesity induce chronic inflammation, which can lead to other diseases such as cancers. Objective: To evaluate the effects of two weight-lowering and anti-inflammatory agents including cinnamon, and turmeric, on serum levels of interleukin-17 (IL-17) as a pro-inflammatory cytokine. Methods: In this study, 64 rats were designated in eight...
متن کاملThe Effects of Low and High Dose Oral Calcium and Phosphor Supplementation on Nephrocalcinosis Diagnosed by Sonography in Premature and Low Birth Weight Neonates
Nephrocalcinosis is defined as calcium deposition in the renal interstitium. One of the major causes of neonatal nephrocalcinosis is the use of calcium and phosphor supplements for premature neonates. This study aims at assessing the effects of calcium and phosphor supplementation in neonatal nephrocalcinosis by renal ultrasonography.In this randomized controlled trial, 37 premature neonates wi...
متن کاملInduction of type 2 diabetes with high concentration and long term fructose intake in male Sprague-Dawley rats
Introduction: High calorie diet is becoming the most important health problem in most developed western societies. Diets with high caloric contents such as high fructose intake are associated with increasing risk of type two diabetes (T2D) and insulin resistance (IR). However, large differences have been seen in the dose and duration of fructose consumption to induction of T2D. Interest to deve...
متن کاملPmn-19: A Comparison of Neonatal Outcomes following Transfer of Frozen and Fresh Embryo
Background: Currently, frozen embryo transfers contribute an increasing rate of births from assisted reproductive technologies such as in vitro fertilization (IVF). However, very few studies evaluated the neonatal outcomes from frozen embryo transfer. This study aimed to investigate and compare the neonatal outcomes from frozen embryo transfer versus fresh embryo transfers. Materials and Method...
متن کاملNEONATAL MORTALITY IN RELATION TO BIRTH WEIGHT
730 low birth weight (LBW) neonates and 1460 controls were selected from 13,123 neonates born from October 1988 to June 1989 in 17 hospitals and maternity units in Tehran, and were compared for mortality in the first seven and up to 28 days of life (early neonatal period). In this study all low birth weight newborns are divided according to four sub-groups of birth weight, and the mortalit...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 9 شماره
صفحات -
تاریخ انتشار 2017